Description

// SYSTEM_ORIGIN

MOTS-c is a 16-amino-acid peptide encoded entirely within the 12S rRNA gene of mitochondrial DNA. Discovered in 2015 by Dr. Pinchas Cohen’s lab at USC, it represents one of the first peptides ever found to be encoded by mitochondrial DNA and act like a hormone on the rest of the body. Levels naturally rise with physical activity — which is why researchers call it an “exercise-mimetic” peptide.

// RESEARCH_VECTORS

• Metabolic Health — Studied for insulin sensitivity, glucose regulation, and metabolic markers
• Exercise Biology — Naturally rises with physical activity; associated with exercise-like metabolic signaling
• Body Composition — Animal studies report reductions in fat accumulation alongside maintained muscle
• Longevity Research — Animal models show extended healthspan and reduced age-related metabolic decline

// MECHANISM_EFFECTS

• AMPK Activation — Activates your body’s master energy-sensing switch
• GLUT4 / Insulin Sensitivity — Reported improvements in glucose uptake and insulin response in muscle tissue
• Fat Metabolism — Animal studies report increased fatty acid oxidation and reduced fat accumulation

// RESEARCH_PROTOCOL

Most research protocols reference 5–10mg administered 3–5x weekly via subcutaneous injection. Some researchers cycle 4–6 weeks on with periodic breaks. Reconstitute with bacteriostatic water; store refrigerated.

// RESEARCH_DISCLAIMER

Research use only. Animal data dominant. Human trials early-stage. Not FDA approved. Not intended for human consumption. Educational content only — not medical advice.